FAQs Literature Refs Safety DEMONSTRATED EFFICACY OF REGENERATIVE CELL THERAPY Human clinical trials: Crohn's fistula1 Stroke2 Ongoing human clinical trials: Advanced heart failure Heart bypass surgical trial Osteoarthritis Fractures Arthritis Liver disease Renal disease Animal models of disease: Osteoarthritis7 Osteochondral defects8 Tendon repair5,9 Fractures10-12 Cerebral infarction13,14 Myocardial infarction15-18 Muscular dystrophy15 Autoimmune disorders19-21 What is Vet-Stem Regenerative Medicine? Regenerative medicine uses a concentrated form of autologous adipose-derived adult stem cells to treat traumatic and degenerative diseases, including bowed tendons, ligament injuries, osteoarthritis, and osteochondral defects in horses and dogs. Success in human clinical trials and animal models Despite its infancy, regenerative medicine is not new. Success in numerous animal models of disease and emerging success in human clinical trials for Crohn's fistulas1 and stroke2, along with hundreds of ongoing clinical trials (See sidebar) support the rationale for stem cell use, and now success, in veterinary medicine. Vet-Stem collaborative and clinical research demonstrate positive results in treating horses with tendon and ligament injuries, osteochondral defects, and osteoarthritis.3-6 Stem cells are multipotent and can differentiate into tendon, ligament, bone, cartilage, cardiac, nerve, muscle, blood vessels, fat, and liver tissue22, 23 (see figure below). The stromal fraction that is harvested from adipose tissue is a heterogeneous mixture of regenerative cells (see below). Vet-Stem Technology: Summary Vet-Stem Regenerative Cell Therapy is based on a clinical technology originally licensed from Artecel Inc., Sunnyvale, CA. Original patents from University of Pittsburgh and Duke University. Rationale based on consistent therapeutic success in numerous animal models of disease (see sidebar) Adipose-derived adult stem cells (Vet-Stem Regenerative Cells: VSRC™) Autologous cell therapy Currently used in horses with bowed tendons, ligament injuries, and fractures, and in dogs with osteoarthritis More than 2,000 horses treated since 2003 No systemic adverse events reported and < 0.5% local tissue reactions.3-6 Demonstrated efficacy with VSRC therapy in horses and dogs Cornell University double-blind, placebo controlled study5 Retrospective studies3,4 Case studies6 Why use adipose-derived regenerative cells rather than regenerative cells derived from bone marrow? Adipose-derived regenerative cells are: Readily available source Can be collected in far greater concentrations than those from bone marrow24 Able to differentiate into multiple lineages implicating their potential in bone, cartilage, and cardiac repair23 (See figure above) Fractions isolated from adipose tissue contain a heterogeneous mixture of regenerative cells, including:23 Mesenchymal stem cells Endothelial progenitor cells Pericytes Immune cells Fibroblasts Other growth factor-secreting bioactive cells Differences in Regenerative Medicine compared to traditional medicine; Does not rely on a single target receptor or a single pathway for its action Regenerative cell mixture is delivered either directly to the traumatic wound (e.g.: tendonitis, desmitis, fracture) or are delivered systemically (e.g.: liver disease, renal disease) Regenerative cells can differentiate into many tissue types, induce repair, and stimulate regeneration22 Regenerative cells "communicate" with the cells of their local environment through paracrine and autocrine modalities, creating the optimal environment for natural healing25 Regenerative cells produce a variety of both secreted and cell surface substances that regulate tissue growth, integrity, and function25 > More Information: Click Here <